Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20718868 | 0.87 | ALDH1A1 (0.60) | CNR1ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL22145338 | 0.86 | ALDH1A1 (0.62) | CNR1ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL27524629 | 0.86 | RAB9A (0.62) | CNR1ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9137509 | 0.86 | ALDH1A1 (0.59) | CNR1ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3999174 | 0.85 | APOBEC3A (0.58) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1695076 | 0.83 | SMN1; SMN2 (0.66) | CNR1ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6959797 | 0.82 | KDM4E (0.62) | CNR1ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6958219 | 0.82 | SMN1; SMN2 (0.68) | ALDH1A1RAB9ASMN1; SMN2NPC1TAAR1 | |
| SCHEMBL8233676 | 0.79 | MAPT (0.65) | CNR1ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9059825 | 0.78 | TSHR (0.60) | CNR1ALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011024078-A1 | 3 -OXOPIPERAZINIUM DERIVATIVES AS AGONISTS OF NERVE GROWTH FACTOR AND THEIR USE AS MEDICAMENTS | INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PII SUNYER (IDIBAPS) (ES) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011024078-A1 | 3 -OXOPIPERAZINIUM DERIVATIVES AS AGONISTS OF NERVE GROWTH FACTOR AND THEIR USE AS MEDICAMENTS | INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PII SUNYER (IDIBAPS) (ES) | 2011-03-03 | — | — | WO | disclosed |
| EP-2289882-A1 | 3-oxopiperazinium derivatives as agonists of nerve growth factor and their use as medicaments | Institut d'Investigacions Biomédiques August PI I Sunyer (ES) | 2011-03-02 | — | — | EP | disclosed |
| EP-2289882-A1 | 3-oxopiperazinium derivatives as agonists of nerve growth factor and their use as medicaments | Institut d'Investigacions Biomédiques August PI I Sunyer (ES) | 2011-03-02 | — | — | EP | disclosed |
| US-7351389-B2 | Aminocarboxylate ligands having substituted aromatic amide moieties | BRACCO INTERNATIONAL B.V. (NL) | 2008-04-01 | — | — | US | disclosed |
| US-20050090689-A1 | Aminocarboxylate ligands having substituted aromatic amide moieties | BRACCO INTERNATIONAL B.V. (NL) | 2005-04-28 | — | — | US | disclosed |
| US-6875864-B2 | Aminocarboxylate ligands having substituted aromatic amide moieties | BRACCO INTERNATIONAL B.V. (NL) | 2005-04-05 | — | — | US | disclosed |
| US-20030171561-A1 | Aminocarboxylate ligands having substituted aromatic amide moieties | BRACCO SUISSE SA (CH) | 2003-09-11 | — | — | US | disclosed |
| EP-0543482-B1 | Aminocarboxylate ligands having substituted aromatic amide moieties | BRACCO INT BV (NL) | 2002-02-06 | — | — | EP | disclosed |
| EP-0543482-A1 | Aminocarboxylate ligands having substituted aromatic amide moieties | BRACCO INTERNATIONAL B.V. (NL) | 1993-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171561-A1 | Aminocarboxylate ligands having substituted aromatic amide moieties | ARGLU1, PRMT1, AADAC | CNR1 512/4885ALDH1A1 741/4885RAB9A 272/4885 |
| US-20050090689-A1 | Aminocarboxylate ligands having substituted aromatic amide moieties | AADAC, ANXA3, AAAS | CNR1 634/4885ALDH1A1 691/4885RAB9A 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.