Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27804378 | 1.00 | PRMT5 (0.32) | PRMT5WDR77ALDH1A1HPGDMEN1 | |
| SCHEMBL4872833 | 0.78 | ALDH1A1 (0.53) | ALDH1A1HPGDMEN1POLBKMT2A | |
| SCHEMBL8818395 | 0.78 | ALDH1A1 (0.53) | ALDH1A1HPGDMEN1POLBKMT2A | |
| SCHEMBL456636 | 0.75 | PDK1 (0.41) | ALDH1A1HPGDMEN1POLBMAPT | |
| SCHEMBL11152901 | 0.74 | ALDH1A1 (0.56) | ALDH1A1HPGDMEN1POLBMAPT | |
| SCHEMBL6205054 | 0.74 | ALDH1A1 (0.36) | ALDH1A1HPGDMEN1POLBMAPT | |
| SCHEMBL3604296 | 0.74 | ALDH1A1 (0.39) | ALDH1A1HPGDMEN1POLBMAPT | |
| SCHEMBL16950649 | 0.72 | MAPT (0.36) | ALDH1A1HPGDMAPTTSHR | |
| SCHEMBL11151232 | 0.70 | ALDH1A1 (0.39) | ALDH1A1HPGDMEN1POLBMAPT | |
| SCHEMBL27420001 | 0.70 | ALDH1A1 (0.40) | ALDH1A1HPGDPOLBMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912170-A4 | HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS | MERCK & CO INC (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0912170-A1 | HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS | Merck & Co., Inc. (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997040825-A1 | HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS | MERCK & CO., INC. (US) | 1997-11-06 | — | — | WO | disclosed |