Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456636 | 0.83 | PDK1 (0.41) | ALDH1A1HPGDTSHRTDP1MEN1 | |
| SCHEMBL3604296 | 0.81 | ALDH1A1 (0.39) | ALDH1A1HPGDTSHRTDP1MEN1 | |
| SCHEMBL11152901 | 0.81 | ALDH1A1 (0.56) | ALDH1A1HPGDTSHRTDP1MEN1 | |
| SCHEMBL16950649 | 0.80 | MAPT (0.36) | ALDH1A1HPGDTSHRTDP1MAPT | |
| SCHEMBL8177420 | 0.80 | POLB (0.39) | ALDH1A1HPGDTSHRTDP1MEN1 | |
| SCHEMBL28355811 | 0.78 | ALOX15 (0.40) | ALDH1A1HPGDTSHRTDP1MEN1 | |
| SCHEMBL11151232 | 0.77 | ALDH1A1 (0.39) | ALDH1A1HPGDTSHRTDP1MEN1 | |
| SCHEMBL28277263 | 0.77 | POLB (0.36) | ALDH1A1HPGDTSHRTDP1MEN1 | |
| SCHEMBL27420001 | 0.77 | ALDH1A1 (0.40) | ALDH1A1HPGDTDP1POLBMAPT | |
| SCHEMBL8876153 | 0.76 | CYP1A2 (0.40) | ALDH1A1MEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545523-A1 | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS | Astex Technology Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |