SCHEMBL6958469

SCHEMBL6958469

COc1nc2c(cc1NC(=S)Oc1ccccc1)CCC2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.37
CDK5 Q00535 2/20 0.36
CDK5R1 Q15078 2/20 0.36
CCNA2 P20248 1/20 0.36
CDK2 P24941 1/20 0.36
SMN1; SMN2 Q16637 5/20 0.36
ALDH1A1 P00352 3/20 0.36
RAB9A P51151 2/20 0.36
RXFP1 Q9HBX9 1/20 0.36
MAPT P10636 4/20 0.35
POLB P06746 4/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
HTT P42858 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
TP53 P04637 6/20 0.33
GAA P10253 2/20 0.33
KMT2A Q03164 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6960236 0.98 CCNA2 (0.38) NPC1CDK5CDK5R1CCNA2CDK2
SCHEMBL6956149 0.86 ALDH1A1 (0.44) NPC1SMN1; SMN2ALDH1A1RAB9AMAPT
SCHEMBL6966387 0.84 ALDH1A1 (0.44) SMN1; SMN2ALDH1A1MAPTPOLBCYP1A2
SCHEMBL6962164 0.77 MAPT (0.35) SMN1; SMN2ALDH1A1RAB9ARXFP1MAPT
SCHEMBL6956523 0.77 RAB9A (0.40) NPC1SMN1; SMN2ALDH1A1RAB9AMAPT
SCHEMBL8088990 0.76 MAPT (0.39) NPC1SMN1; SMN2ALDH1A1RAB9ARXFP1
SCHEMBL6960231 0.74 HTT (0.41) NPC1CDK5CDK5R1CCNA2CDK2
SCHEMBL8699464 0.73 MAPT (0.37) NPC1SMN1; SMN2ALDH1A1RAB9AMAPT
SCHEMBL6956205 0.72 SMN1; SMN2 (0.43) NPC1SMN1; SMN2ALDH1A1RAB9AMAPT
SCHEMBL6961512 0.72 PHGDH (0.53) NPC1POLBCYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0850222-B1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARM CO LTD (KR) 2003-05-28 EP disclosed
US-6028195-A AN ANTITUMOR AGENT WITH VERY LOW TOXICITIES SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2000-02-22 US disclosed
EP-0850222-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF Samjin Pharmaceutical Co., Ltd. (KR) 1998-07-01 EP disclosed
WO-1998000402-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARMACEUTICAL CO., LTD. (KR) 1998-01-08 WO disclosed