SCHEMBL6959999

SCHEMBL6959999

COc1ccc(CCSc2c(O)cc(-c3ccccc3)oc2=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 1/20 0.46
NTRK2 Q16620 1/20 0.46
MAPT P10636 3/20 0.45
NPC1 O15118 2/20 0.45
CYP3A4 P08684 2/20 0.45
ABCB1 P08183 2/20 0.45
ABCG2 Q9UNQ0 2/20 0.45
CYP2C9 P11712 1/20 0.45
TSHR P16473 1/20 0.45
CYP2C19 P33261 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.44
KDM4E B2RXH2 2/20 0.44
ALDH1A1 P00352 2/20 0.44
HPGD P15428 2/20 0.44
TNKS O95271 2/20 0.44
CYP19A1 P11511 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
ACHE P22303 2/20 0.43
PPARG P37231 1/20 0.43
FAAH O00519 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6957750 0.90 ABCB1 (0.44) NTRK1NTRK2MAPTNPC1CYP3A4
SCHEMBL6960622 0.89 SMN1; SMN2 (0.49) NTRK2MAPTNPC1CYP3A4ABCB1
SCHEMBL6956208 0.89 NTRK1 (0.48) NTRK1NTRK2MAPTNPC1CYP3A4
SCHEMBL6954657 0.87 SMN1; SMN2 (0.44) MAPTCYP3A4ABCB1CYP2C9CYP2C19
SCHEMBL6958649 0.86 NTRK1 (0.51) NTRK1NTRK2MAPTNPC1CYP3A4
SCHEMBL6957097 0.86 CYSLTR1 (0.41) NTRK1NTRK2MAPTABCB1SMN1; SMN2
SCHEMBL6952547 0.84 ABCB1 (0.50) MAPTABCB1CYP2C19ACHEPTGS2
SCHEMBL6956331 0.84 SLC16A3 (0.46) MAPTNPC1ABCB1ACHEMAOB
SCHEMBL6956148 0.83 PTGES (0.45) MAPTNPC1CYP3A4ABCB1ABCG2
SCHEMBL6963458 0.83 SMN1; SMN2 (0.46) NTRK2MAPTCYP3A4ABCB1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US claimed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP claimed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO claimed
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
US-6005103-A TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS WARNER-LAMBERT COMPANY (US) 1999-12-21 US disclosed
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed