Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 8/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 3/20 | 0.31 |
| ▸ | CTSG | P08311 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6958976 | 1.00 | FAAH (0.38) | FAAHMGLLCYP19A1CHRM1PRMT5 | |
| Bromide SCHEMBL6969245 | 0.81 | FAAH (0.42) | FAAHMGLLCYP19A1CHRM1ELANE | |
| Bromide SCHEMBL6968332 | 0.81 | FAAH (0.42) | FAAHMGLLCYP19A1CHRM1ELANE | |
| Bromide SCHEMBL6969237 | 0.81 | FAAH (0.42) | FAAHMGLLCYP19A1CHRM1ELANE | |
| SCHEMBL6954836 | 0.81 | SIGMAR1 (0.33) | FAAHMGLLCYP19A1CHRM1ELANE | |
| Bromide SCHEMBL6968325 | 0.81 | FAAH (0.42) | FAAHMGLLCYP19A1CHRM1ELANE | |
| SCHEMBL6963346 | 0.81 | SIGMAR1 (0.33) | FAAHMGLLCYP19A1CHRM1ELANE | |
| Bromide SCHEMBL2672194 | 0.80 | FAAH (0.41) | FAAHMGLLCYP19A1CHRM1ELANE | |
| Bromide SCHEMBL2460258 | 0.80 | FAAH (0.41) | FAAHMGLLCYP19A1CHRM1ELANE | |
| Bromide SCHEMBL6962170 | 0.80 | FAAH (0.41) | FAAHMGLLCYP19A1CHRM1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0849269-B9 | Vinyl pyrrolidine cephalosporins with basic substituents | BASILEA PHARMACEUTICA AG (CH) | 2003-03-05 | — | — | EP | disclosed |
| EP-0849269-B1 | Vinyl pyrrolidine cephalosporins with basic substituents | BASILEA PHARMACEUTICA AG (CH) | 2002-07-10 | — | — | EP | disclosed |
| US-5981519-A | Vinyl-pyrrolidinone cephalosporins | HOFFMAN-LA ROCHE INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0849269-A1 | Vinyl pyrrolidine cephalosporins with basic substituents | F. HOFFMANN-LA ROCHE AG (CH) | 1998-06-24 | — | — | EP | disclosed |