Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ASPH | Q12797 | 2/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031057 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAATRKDM4CKDM5A | |
| SCHEMBL83616 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAKDM4CKDM5AP2RX7 | |
| SCHEMBL29486104 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAKDM4CKDM5AP2RX7 | |
| SCHEMBL1760077 | 0.83 | KDM4E (0.43) | SMN1; SMN2LMNAATRKDM4EALDH1A1 | |
| SCHEMBL30961407 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAATRKDM4CKDM5A | |
| SCHEMBL6637378 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAATRKDM4CKDM5A | |
| SCHEMBL29741249 | 0.83 | KDM4E (0.43) | SMN1; SMN2LMNAATRKDM4EALDH1A1 | |
| SCHEMBL27488847 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAKDM4CKDM5AP2RX7 | |
| SCHEMBL30961379 | 0.78 | GSK3B (0.41) | SMN1; SMN2LMNAATRKDM4CKDM5A | |
| SCHEMBL6967775 | 0.78 | ATR (0.39) | SMN1; SMN2LMNAATRKDM4CKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |