SCHEMBL83616

SCHEMBL83616

O=C(O)c1ccnc(Cl)c1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.59
LMNA P02545 1/20 0.59
KDM4C Q9H3R0 3/20 0.47
KDM5A P29375 1/20 0.47
KDM4E B2RXH2 5/20 0.47
ASPH Q12797 1/20 0.47
KDM8 Q8N371 1/20 0.47
TSHR P16473 3/20 0.47
TDP1 Q9NUW8 2/20 0.42
CASP1 P29466 1/20 0.42
L3MBTL1 Q9Y468 3/20 0.42
KDM4A O75164 2/20 0.42
RAB9A P51151 1/20 0.42
EGLN1 Q9GZT9 1/20 0.42
HIF1AN Q9NWT6 1/20 0.42
ALDH1A1 P00352 4/20 0.41
MAPT P10636 2/20 0.41
CYP3A4 P08684 1/20 0.41
ALOX15 P16050 1/20 0.41
BLM P54132 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29486104 1.00 SMN1; SMN2 (0.59) SMN1; SMN2LMNAKDM4CKDM5AKDM4E
SCHEMBL27488847 0.98 SMN1; SMN2 (0.57) SMN1; SMN2LMNAKDM4CKDM5AKDM4E
SCHEMBL28522400 0.86 SMN1; SMN2 (0.46) SMN1; SMN2LMNAKDM4CKDM5AKDM4E
SCHEMBL6959623 0.84 SMN1; SMN2 (0.45) SMN1; SMN2LMNAKDM4CKDM5AKDM4E
SCHEMBL1031057 0.83 SMN1; SMN2 (0.44) SMN1; SMN2LMNAKDM4CKDM5AKDM4E
Ethyl Acetate SCHEMBL28335611 0.82 LMNA (0.42) SMN1; SMN2LMNAKDM4CKDM5AKDM4E
SCHEMBL19857453 0.81 KDM4E (0.60) SMN1; SMN2LMNAKDM4CKDM5AKDM4E
SCHEMBL6637378 0.81 SMN1; SMN2 (0.42) SMN1; SMN2LMNAKDM4CKDM5AKDM4E
SCHEMBL30961407 0.81 SMN1; SMN2 (0.42) SMN1; SMN2LMNAKDM4CKDM5AKDM4E
SCHEMBL1760077 0.81 KDM4E (0.43) SMN1; SMN2LMNAKDM4ETDP1CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 747 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116768796-A Novel pyrazole-3-carboxamide derivative and preparation method and application thereof 河北农业大学 2023-09-19 CN claimed
CN-115643963-A Method for promoting growth of moringa oleifera by using composite growth promoting strain 云南省热带作物科学研究所 2023-01-31 CN claimed
CN-114292221-A Synthetic method and application of 2-aryl indole compound 河北农业大学 2022-04-08 CN claimed
CN-114145115-A Method for cultivating new variety of ultrahigh-yield wheat 潘捷文 2022-03-08 CN claimed
CN-110226473-A A kind of implantation methods of High-yield Wheat 山西省农业科学院农作物品种资源研究所 2019-09-13 CN claimed
CN-110226504-A A kind of cultural method promoting Resistance of Wheat To Adversity 山西省农业科学院农作物品种资源研究所 2019-09-13 CN claimed
CN-208436831-U A kind of dichloro-isonicotinic acid preparation facilities 浙江荣凯科技发展有限公司 2019-01-29 CN claimed
CN-107619408-A A kind of aminothiazole carboxylic acid derivates and its production and use 南开大学 2018-01-23 CN claimed
CN-107459515-A A kind of chiral 5,6-tetrahydropyridine derivative and its production and use 南开大学 2017-12-12 CN claimed
CN-107459514-A A kind of chiral piperidine derivative and its production and use 南开大学 2017-12-12 CN claimed
CN-1434046-A Novel intermediate for preparing camptothecin derivative (CPT-11) and correlated compound and method thereof PHARMACIA & UPJOHN CO LLC (US) 2003-08-06 CN claimed
CN-1434044-A Novel intermediate for preparing camptothecin derivative (CPT-11) and correlated compound and method thereof PHARMACIA & UPJOHN CO LLC (US) 2003-08-06 CN claimed
US-6582961-B1 Generating disease resistant plants; obtain plant, incubate with vector coding preferential enzymatic polypeptides, transform, recover transformed plants, propagate, monitor plant resistance to disease REDOX CHEMICALS, INC. 2003-06-24 US claimed
WO-2003033712-A1 CHEMICALLY INDUCIBLE PROMOTERS FROM BARLEY AND USE THEREOF BASF PLANT SCIENCE GMBH (DE) 2003-04-24 WO claimed
CN-1100058-C Intermediates and processes for the preparation of camptothecin derivatives (CPT-11) and related compounds UPJOHN CO (US) 2003-01-29 CN claimed
EP-1135026-A1 NOVEL METHODS OF PROTECTING PLANTS FROM PATHOGENS Redox Chemicals, Inc. (US) 2001-09-26 EP claimed
WO-2000032048-A1 NOVEL METHODS OF PROTECTING PLANTS FROM PATHOGENS REDOX CHEMICALS, INC. (US) 2000-06-08 WO claimed
CN-1181083-A Novel intermediates and processes for the preparation of camptothecin derivatives (CPT-11) and related compounds UPJOHN CO (US) 1998-05-06 CN claimed
EP-0332104-A2 Chemically regulatable DNA sequences and genes and uses thereof CIBA-GEIGY AG (CH) 1989-09-13 EP claimed
CN-87106598-A Protective plant is avoided the method for disease 1988-05-04 CN claimed