SCHEMBL6963458

SCHEMBL6963458

O=c1oc(-c2ccccc2)cc(O)c1SCCCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
POLB P06746 1/20 0.46
GPR84 Q9NQS5 3/20 0.43
ABCB1 P08183 5/20 0.40
MAPT P10636 5/20 0.39
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
ALOX15 P16050 4/20 0.39
KDM4E B2RXH2 3/20 0.39
ALDH1A1 P00352 3/20 0.39
TP53 P04637 3/20 0.39
CYP3A4 P08684 3/20 0.39
HPGD P15428 3/20 0.39
HSD17B10 Q99714 3/20 0.39
HDAC1 Q13547 2/20 0.39
CYP1A1 P04798 2/20 0.39
CYP1A2 P05177 2/20 0.39
ALOX12 P18054 2/20 0.39
CYP1B1 Q16678 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6964030 0.96 SMN1; SMN2 (0.45) SMN1; SMN2L3MBTL1POLBGPR84ABCB1
SCHEMBL6960622 0.93 SMN1; SMN2 (0.49) SMN1; SMN2L3MBTL1POLBGPR84ABCB1
SCHEMBL6954657 0.88 SMN1; SMN2 (0.44) SMN1; SMN2L3MBTL1POLBGPR84ABCB1
SCHEMBL6956148 0.87 PTGES (0.45) SMN1; SMN2L3MBTL1POLBGPR84ABCB1
SCHEMBL6965496 0.86 ASAH1 (0.41) SMN1; SMN2L3MBTL1POLBGPR84MAPT
SCHEMBL6959678 0.86 SMN1; SMN2 (0.42) SMN1; SMN2L3MBTL1POLBGPR84ABCB1
SCHEMBL6964247 0.85 AR (0.42) SMN1; SMN2L3MBTL1POLBGPR84ABCB1
SCHEMBL6950945 0.85 GSK3B (0.47) SMN1; SMN2L3MBTL1POLBGPR84MEN1
SCHEMBL6958378 0.85 MAOA (0.45) ABCB1XDHMAOAMAOB
SCHEMBL6956056 0.84 TNKS (0.47) SMN1; SMN2L3MBTL1POLBGPR84ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
US-6005103-A TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS WARNER-LAMBERT COMPANY (US) 1999-12-21 US disclosed
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed