Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.49 |
| ▸ | RBP4 | P02753 | 13/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007618 | 0.78 | HTR2C (0.75) | HTR2CRBP4GAATDP1CYP2D6 | |
| SCHEMBL8149738 | 0.77 | HTR2C (0.49) | HTR2CTRPV6RBP4SLC2A1GAA | |
| SCHEMBL4067584 | 0.75 | HTR2C (0.66) | HTR2CRBP4GAATDP1CYP2D6 | |
| Cyanide SCHEMBL27792035 | 0.75 | HTR2C (0.70) | HTR2CRBP4GAATDP1CYP2D6 | |
| SCHEMBL6964019 | 0.75 | TRPV6 (0.53) | TRPV6GAA | |
| SCHEMBL29721046 | 0.71 | HTR2C (0.70) | HTR2CRBP4GAATDP1CYP2D6 | |
| SCHEMBL1919230 | 0.71 | HTR2C (0.70) | HTR2CRBP4GAATDP1CYP2D6 | |
| SCHEMBL28247607 | 0.71 | HTR2C (0.70) | HTR2CRBP4GAATDP1CYP2D6 | |
| SCHEMBL12897998 | 0.71 | HTR2C (0.52) | HTR2CTRPV6RBP4SLC2A1CYP2D6 | |
| SCHEMBL14945579 | 0.71 | RBP4 (0.61) | HTR2CRBP4GAACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | claimed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | claimed |
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |