Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9036686 | 0.82 | TRPV6 (0.59) | TRPV6KDM4EALDH1A1OPRM1OPRL1 | |
| SCHEMBL8142385 | 0.80 | TRPV6 (0.52) | TRPV6KDM4EALDH1A1OPRM1OPRL1 | |
| SCHEMBL11793878 | 0.76 | TRPV6 (0.48) | TRPV6OPRM1OPRL1OPRD1HDAC4 | |
| SCHEMBL6960038 | 0.75 | HTR2C (0.50) | TRPV6GAA | |
| SCHEMBL7040982 | 0.74 | TRPV6 (0.63) | TRPV6KDM4EALDH1A1OPRM1OPRL1 | |
| SCHEMBL8142382 | 0.73 | TRPV6 (0.46) | TRPV6KDM4EALDH1A1OPRL1HDAC4 | |
| SCHEMBL1919333 | 0.72 | HDAC4 (0.57) | TRPV6OPRM1OPRL1OPRD1HDAC4 | |
| SCHEMBL29721204 | 0.72 | HDAC4 (0.57) | TRPV6OPRM1OPRL1OPRD1HDAC4 | |
| SCHEMBL18671231 | 0.71 | HDAC4 (0.55) | TRPV6OPRM1OPRL1OPRD1HDAC4 | |
| SCHEMBL7038208 | 0.70 | TRPV6 (0.62) | TRPV6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |