Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955537 | 0.83 | CYP2D6 (0.47) | MAPTALDH1A1CYP2D6CYP2C9MEN1 | |
| SCHEMBL6960064 | 0.81 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6955057 | 0.77 | BRD4 (0.57) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6970670 | 0.77 | CYP2D6 (0.51) | ALDH1A1CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL7348149 | 0.75 | PDE4B (0.69) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7351761 | 0.74 | MAPT (0.46) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7353521 | 0.73 | AVPR1A (0.52) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7348484 | 0.72 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7346702 | 0.71 | CA1 (0.48) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7355244 | 0.71 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620216-B1 | Benzamide derivatives and their use as vasopressin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5521170-A | VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-28 | — | — | US | disclosed |
| EP-0620216-A1 | Benzamide derivatives and their use as vasopressin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-19 | — | — | EP | disclosed |