Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955537 | 0.85 | CYP2D6 (0.47) | CYP2D6CYP2C9RAB9ASMN1; SMN2HPGD | |
| SCHEMBL6955335 | 0.81 | CYP2D6 (0.47) | CYP2D6CYP2C9AVPR2AVPR1ARAB9A | |
| SCHEMBL6970673 | 0.76 | AVPR2 (0.48) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL6969600 | 0.75 | AVPR2 (0.46) | CYP2D6AVPR2AVPR1ARAB9ASMN1; SMN2 | |
| SCHEMBL7351134 | 0.74 | AVPR2 (0.59) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL6955225 | 0.73 | AVPR2 (0.73) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL6967260 | 0.72 | AVPR2 (0.48) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL7350669 | 0.71 | AVPR2 (0.58) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL6960127 | 0.70 | NPSR1 (0.49) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL8559469 | 0.70 | AVPR2 (0.65) | AVPR2AVPR1ARAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620216-B1 | Benzamide derivatives and their use as vasopressin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5521170-A | VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-28 | — | — | US | disclosed |
| EP-0620216-A1 | Benzamide derivatives and their use as vasopressin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-19 | — | — | EP | disclosed |