SCHEMBL6960106

SCHEMBL6960106

CC(C)c1ccccc1Sc1c(O)cc(-c2ccc(OCc3ccncc3)cc2)oc1=O

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.39
ABCB1 P08183 1/20 0.38
MAPT P10636 1/20 0.38
TERT O14746 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
AR P10275 1/20 0.37
GAA P10253 1/20 0.37
HPGD P15428 1/20 0.37
PTPN1 P18031 1/20 0.36
ADAMTS4 O75173 1/20 0.36
MMP13 P45452 1/20 0.36
MAOA P21397 1/20 0.36
ACHE P22303 1/20 0.36
MAOB P27338 1/20 0.36
S1PR1 P21453 1/20 0.36
S1PR5 Q9H228 1/20 0.36
PTGER4 P35408 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6965151 0.93 ABCB1 (0.45) ABCB1MAPTL3MBTL1PTPN1MAOA
SCHEMBL6959848 0.90 ADAMTS4 (0.40) ABCB1MAPTTERTPTPN1ADAMTS4
Cyclohexane SCHEMBL6955484 0.88 ADAMTS4 (0.39) TERTPTPN1ADAMTS4ACHEMAOB
Cyclopentane SCHEMBL6955464 0.88 ADAMTS4 (0.39) TERTPTPN1ADAMTS4ACHEMAOB
Cyclopropane SCHEMBL6955630 0.88 ADAMTS4 (0.39) TERTPTPN1ADAMTS4ACHEMAOB
SCHEMBL6960294 0.87 QPCT (0.39) ABCB1MAPTL3MBTL1
SCHEMBL6955506 0.87 RECQL (0.36) TERTMAOBPTGER4
SCHEMBL6954863 0.85 ABCB1 (0.39) ABCB1MAPTHPGDMAOAACHE
SCHEMBL8537357 0.83 ABCB1 (0.44) ABCB1MAPTGAAHPGDMAOA
SCHEMBL6958498 0.83 XDH (0.45) MAPTL3MBTL1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US claimed
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
US-6005103-A TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS WARNER-LAMBERT COMPANY (US) 1999-12-21 US disclosed
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed