SCHEMBL6960130

SCHEMBL6960130

O=C(c1ccccc1)[N+]1([O-])CCCCC1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.45
HPGD P15428 3/20 0.45
KMT2A Q03164 3/20 0.45
CA2 P00918 2/20 0.41
CA4 P22748 2/20 0.41
CES1 P23141 3/20 0.41
CES2 O00748 2/20 0.41
TSHR P16473 2/20 0.41
DAO P14920 1/20 0.41
NAPRT Q6XQN6 1/20 0.41
HTT P42858 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
RAB9A P51151 1/20 0.39
CYP3A4 P08684 2/20 0.38
MAPT P10636 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
POLB P06746 1/20 0.38
PARP1 P09874 1/20 0.38
CYP2C19 P33261 1/20 0.38
RECQL P46063 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7338845 0.94 CA2 (0.43) ALDH1A1HPGDKMT2ACA2CA4
SCHEMBL15297897 0.81 ALDH1A1 (0.46) ALDH1A1HPGDKMT2ACA2CA4
SCHEMBL8676355 0.80 CA1 (0.47) ALDH1A1KMT2ACA2CES1CES2
SCHEMBL18040632 0.80 CA2 (0.39) ALDH1A1HPGDKMT2ACA2CA4
SCHEMBL15297890 0.78 CES1 (0.44) ALDH1A1HPGDKMT2ACA2CA4
SCHEMBL15297896 0.78 ALDH1A1 (0.51) ALDH1A1HPGDKMT2ACA2CA4
SCHEMBL7703260 0.77 CES1 (0.42) ALDH1A1HPGDKMT2ACA2CA4
SCHEMBL15297925 0.76 ALDH1A1 (0.42) ALDH1A1HPGDKMT2ACA2CA4
SCHEMBL6978869 0.76 NPC1 (0.44) ALDH1A1HPGDTSHRHTTL3MBTL1
SCHEMBL15297887 0.75 HPGD (0.49) ALDH1A1HPGDKMT2ACA2CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787724-B1 NOVEL INTERMEDIATE FOR PRODUCTION AND PROCESS FOR PRODUCING PYRIDINE DERIVATIVE TAIHO PHARMACEUTICAL CO LTD (JP) 2003-04-16 EP disclosed
US-5919778-A Cyclic amide derivatives EISAI CO., LTD. (JP) 1999-07-06 US disclosed
US-5753647-A PLATELET ACTIVATING FACTOR ANTAGONIST BOEHRINGER INGELHEIM KG (DE) 1998-05-19 US disclosed
US-5734059-A Production intermediate and process for producing pyridine derivative TAIHO PHARMACEUTICAL CO., LTD. (JP) 1998-03-31 US disclosed
EP-0787724-A1 NOVEL INTERMEDIATE FOR PRODUCTION AND PROCESS FOR PRODUCING PYRIDINE DERIVATIVE TAIHO PHARMACEUTICAL CO., LTD. (JP) 1997-08-06 EP disclosed
US-5654308-A PREVENT OR TREAT DISEASE DUE TO INSUFFICIENT CHOLINE FUNCTION EISAI CO., LTD. (JP) 1997-08-05 US disclosed
US-5620976-A PREVENTION AND TREATMENT OF DISEASES DUE TO INSUFFICIENCY OF THE CENTRAL CHOLINE FUNCTIONS EISAI CO., LTD. (JP) 1997-04-15 US disclosed
EP-0742216-A2 Cyclic amide derivatives Eisai Co., Ltd. (JP) 1996-11-13 EP disclosed
US-5521182-A ACETYLCHOLINESTERASE INHIBITORS EISAI CO., LTD. (JP) 1996-05-28 US disclosed
US-5504088-A ACETYLCHOLINE ESTERASE INHIBITORS; ALZHEIMER'S DISEASE AND OTHER DISEASES CAUSED BY A LOW CONCENTRATION OF CHOLINE EISAI CO., LTD. (JP) 1996-04-02 US disclosed
EP-0677516-A1 Cyclic amide derivatives Eisai Co., Ltd. (JP) 1995-10-18 EP disclosed
US-5292735-A Cyclic amide derivatives EISAI CO., LTD. (JP) 1994-03-08 US disclosed
EP-0503471-A1 Acylaminosubstituted hetrazepines BOEHRINGER INGELHEIM KG (DE) 1992-09-16 EP disclosed
EP-0468187-A2 Cyclic amide derivatives Eisai Co., Ltd. (JP) 1992-01-29 EP disclosed