Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 7/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25640464 | 0.81 | TACR1 (0.47) | GNAI3CYP2D6USP2MEN1KMT2A | |
| SCHEMBL7001684 | 0.79 | TACR1 (0.53) | GNAI3CYP2D6USP2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6539724 | 0.78 | TACR1 (0.53) | GNAI3CYP2D6USP2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6540449 | 0.78 | TACR1 (0.53) | GNAI3CYP2D6USP2MEN1KMT2A | |
| SCHEMBL3272931 | 0.78 | SIGMAR1 (0.54) | CYP2D6MEN1KMT2A | |
| SCHEMBL3277741 | 0.78 | SIGMAR1 (0.54) | CYP2D6MEN1KMT2A | |
| SCHEMBL3272922 | 0.78 | SIGMAR1 (0.54) | CYP2D6MEN1KMT2A | |
| SCHEMBL7013419 | 0.76 | GSK3B (0.42) | PDE10A | |
| SCHEMBL591547 | 0.76 | CYP2D6 (0.74) | GNAI3CYP2D6USP2MEN1KMT2A | |
| SCHEMBL3491470 | 0.75 | LTA4H (0.53) | GNAI3MEN1KMT2AKDM4ETACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927170-B1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2003-10-08 | — | — | EP | disclosed |
| EP-0927170-A1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1999-07-07 | — | — | EP | disclosed |
| US-5892039-A | Piperazino derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1999-04-06 | — | — | US | disclosed |
| US-5798359-A | USEFUL FOR TREATMENT OF RESPIRATORY DISORDERS SUCH AS ASTHMA | SCHERING CORPORATION (US) | 1998-08-25 | — | — | US | disclosed |
| WO-1998008826-A1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1998-03-05 | — | — | WO | disclosed |
| US-5719156-A | ASTHMA | SCHERING CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |