Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969011 | 0.86 | KCNH2 (0.48) | DRD2KCNH2NPC1RAB9AMAPT | |
| SCHEMBL6961517 | 0.81 | DRD2 (0.54) | DRD2KCNH2NPC1RAB9AMAPT | |
| SCHEMBL6964471 | 0.79 | DRD2 (0.54) | DRD2KCNH2NPC1RAB9AMAPT | |
| SCHEMBL6966467 | 0.79 | KCNH2 (0.52) | KCNH2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL6967960 | 0.79 | KCNH2 (0.50) | DRD2KCNH2NPC1RAB9AMAPT | |
| SCHEMBL6966566 | 0.79 | KCNH2 (0.50) | DRD2KCNH2NPC1RAB9AMAPT | |
| SCHEMBL1250916 | 0.77 | KCNH2 (0.48) | KCNH2MAPTALDH1A1 | |
| SCHEMBL6961061 | 0.77 | KCNH2 (0.48) | DRD2KCNH2NPC1RAB9AMAPT | |
| SCHEMBL13841588 | 0.75 | NPC1 (0.54) | DRD2NPC1RAB9AKMT2AMGLL | |
| SCHEMBL6967276 | 0.74 | DRD2 (0.55) | DRD2KCNH2MAPTHTR1AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |