Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964471 | 0.79 | DRD2 (0.54) | DRD2KCNH2PIK3CAMAPTHTR1B | |
| SCHEMBL6966311 | 0.79 | KCNH2 (0.52) | DRD2KCNH2HTR1BHTR1ANR3C1 | |
| SCHEMBL6967960 | 0.79 | KCNH2 (0.50) | DRD2KCNH2MAPTHTR1BHTR1A | |
| SCHEMBL6966566 | 0.79 | KCNH2 (0.50) | DRD2KCNH2MAPTHTR1BHTR1A | |
| SCHEMBL19662764 | 0.78 | LRRK2 (0.70) | PIK3CACREBBPLRRK2MAPTMCHR1 | |
| SCHEMBL6963230 | 0.77 | DRD2 (0.53) | DRD2KCNH2PIK3CAMAPTHTR1B | |
| SCHEMBL6957036 | 0.77 | KCNH2 (0.54) | DRD2KCNH2MAPTFLT3NR3C1 | |
| SCHEMBL6961517 | 0.76 | DRD2 (0.54) | DRD2KCNH2MAPTHTR1BHTR1A | |
| SCHEMBL6966876 | 0.75 | CYP11B2 (0.53) | DRD2KCNH2MAPTHTR1BHTR1A | |
| SCHEMBL23762137 | 0.75 | LRRK2 (0.53) | PIK3CACREBBPLRRK2MAPTLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |