Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | CA2 | P00918 | 5/20 | 0.39 |
| ▸ | CA9 | Q16790 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855488 | 0.89 | KMT2A (0.47) | TYMPKMT2ACA12CA1CA2 | |
| SCHEMBL1614716 | 0.89 | KMT2A (0.47) | TYMPKMT2ACA12CA1CA2 | |
| SCHEMBL8897393 | 0.89 | KMT2A (0.47) | TYMPKMT2ACA12CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL29174390 | 0.69 | LMNA (0.40) | TYMPKMT2ACA12CA1CA2 | |
| SCHEMBL11390072 | 0.68 | CA12 (0.64) | TYMPKMT2ACA12CA1CA2 | |
| SCHEMBL15597325 | 0.65 | TYMP (0.56) | TYMPKMT2ACA12CA1CA2 | |
| SCHEMBL9272320 | 0.65 | KMT2A (0.54) | TYMPKMT2ACA12CA1CA2 | |
| SCHEMBL8530813 | 0.65 | LMNA (0.59) | TYMPKMT2ACA12CA1CA2 | |
| SCHEMBL29579255 | 0.65 | CA12 (0.53) | TYMPKMT2ACA12CA1CA2 | |
| SCHEMBL16752479 | 0.65 | CA12 (0.53) | TYMPKMT2ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1148878-A4 | 1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AS RADIODIGANOSTIC AGENTS AND THEIR USE IN DETERMINING HYPOXIA AND RADIORESISTANCE OF TUMORS | FOX CHASE CANCER CT (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1148878-A1 | 1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AS RADIODIGANOSTIC AGENTS AND THEIR USE IN DETERMINING HYPOXIA AND RADIORESISTANCE OF TUMORS | FOX CHASE CANCER CENTER (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000043004-A1 | 1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AS RADIODIGANOSTIC AGENTS AND THEIR USE IN DETERMINING HYPOXIA AND RADIORESISTANCE OF TUMORS | FOX CHASE CANCER CENTER (US) | 2000-07-27 | — | — | WO | disclosed |