Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923385 | 0.79 | SIGMAR1 (0.79) | SIGMAR1MAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL6344083 | 0.78 | SMN1; SMN2 (0.50) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL11213408 | 0.78 | SIGMAR1 (0.77) | SIGMAR1MAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL9271170 | 0.77 | SLC18A3 (0.44) | SIGMAR1MAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL2876304 | 0.76 | SIGMAR1 (0.72) | SIGMAR1MAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL3708916 | 0.75 | ALDH1A1 (0.67) | SIGMAR1MAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL28217942 | 0.75 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL23199732 | 0.73 | SIGMAR1 (0.59) | SIGMAR1MAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL7019866 | 0.72 | MC4R (0.55) | SIGMAR1ALDH1A1 | |
| SCHEMBL15937935 | 0.72 | DRD4 (0.69) | SIGMAR1MAPTL3MBTL1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900211-B1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | UPJOHN CO (US) | 2003-07-02 | — | — | EP | claimed |