Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MC5R | P33032 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28065475 | 0.85 | ADRA2A (0.47) | ADRA2ACYP2A6CYP1A2TRPV1MAPK1 | |
| SCHEMBL17288545 | 0.81 | ADRA2A (0.49) | ADRA2ACYP2A6CYP1A2TRPV1MAPK1 | |
| SCHEMBL15345416 | 0.81 | ADRA2A (0.49) | ADRA2ACYP2A6CYP1A2 | |
| SCHEMBL27320935 | 0.81 | ADRA2A (0.49) | ADRA2ACYP2A6CYP1A2TRPV1 | |
| SCHEMBL6041434 | 0.78 | MAPK1 (0.41) | ADRA2ACYP1A2TRPA1ALDH1A1TSHR | |
| SCHEMBL10391875 | 0.78 | ALDH1A1 (0.34) | CYP2A6CYP1A2TRPA1ALDH1A1TSHR | |
| SCHEMBL17288369 | 0.78 | ADRA2A (0.47) | ADRA2ACYP2A6CYP1A2TRPV1MAPK1 | |
| SCHEMBL9609733 | 0.78 | ALDH1A1 (0.56) | CYP2A6CYP1A2TRPA1ALDH1A1TSHR | |
| SCHEMBL3282476 | 0.77 | CYP1A2 (0.57) | CYP2A6CYP1A2TRPA1ALDH1A1TSHR | |
| SCHEMBL11619289 | 0.77 | ADRA2A (0.46) | ADRA2ACYP2A6CYP1A2TRPV1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183907-C | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | SERVIER LAB (FR) | 2005-01-12 | — | — | CN | disclosed |
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| CN-1257864-A | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | ADIR (FR) | 2000-06-28 | — | — | CN | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |