Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13780967 | 0.80 | HPGD (0.46) | HPGDNPSR1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL13488596 | 0.80 | NPSR1 (0.66) | HPGDNPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL15803898 | 0.77 | NPSR1 (0.47) | HPGDNPSR1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL11652842 | 0.77 | HPGD (0.72) | HPGDALDH1A1MAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL8145766 | 0.72 | CYP1A2 (0.67) | HPGDNPSR1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL11584471 | 0.72 | ALDH1A1 (0.52) | HPGDNPSR1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL6968502 | 0.72 | CYP1A2 (0.43) | HPGDNPSR1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL15806516 | 0.71 | HPGD (0.54) | HPGDALDH1A1MAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL21916084 | 0.67 | BRD4 (0.55) | NPSR1CYP1A2MAPTKDM4ECYP3A4 | |
| SCHEMBL22548001 | 0.66 | RAB9A (0.72) | NPSR1ALDH1A1MAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | claimed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |