Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968272 | 1.00 | CRBN (0.51) | CRBNCREBBPBRD4ITGB3ITGB2 | |
| SCHEMBL6740222 | 0.75 | CRBN (0.56) | CRBNALDH1A1MAPK1FFAR1NPC1 | |
| SCHEMBL6977466 | 0.73 | CRBN (0.53) | CRBNCREBBPBRD4ITGB3ITGB2 | |
| SCHEMBL6976609 | 0.73 | CRBN (0.53) | CRBNCREBBPBRD4ITGB3ITGB2 | |
| SCHEMBL8428351 | 0.73 | ITGB1 (0.53) | CRBNCREBBPBRD4ITGB3ITGB2 | |
| SCHEMBL8428350 | 0.73 | ITGB1 (0.53) | CRBNCREBBPBRD4ITGB3ITGB2 | |
| SCHEMBL8522217 | 0.71 | CRBN (0.47) | CRBNCREBBPBRD4ALDH1A1DDB1 | |
| SCHEMBL11036165 | 0.71 | CRBN (0.47) | CRBNCREBBPBRD4ALDH1A1DDB1 | |
| SCHEMBL8439360 | 0.71 | CRBN (0.47) | CRBNCREBBPBRD4ALDH1A1DDB1 | |
| SCHEMBL7385157 | 0.71 | HDAC8 (0.47) | CRBNCREBBPBRD4ITGB3ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023265-B1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM CA LTD (CA) | 2003-01-15 | — | — | EP | disclosed |
| US-6211170-B1 | Azetidinone derivatives for the treatment of HCMV infections | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2001-04-03 | — | — | US | disclosed |
| EP-1023265-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999018073-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 1999-04-15 | — | — | WO | disclosed |