Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 7/20 | 0.39 |
| ▸ | BRD4 | O60885 | 6/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8522217 | 1.00 | CRBN (0.47) | CRBNDDB1CREBBPBRD4EP300 | |
| SCHEMBL11036165 | 1.00 | CRBN (0.47) | CRBNDDB1CREBBPBRD4EP300 | |
| SCHEMBL9256649 | 0.80 | CRBN (0.51) | CRBNDDB1CREBBPGAA | |
| SCHEMBL9257239 | 0.80 | CRBN (0.51) | CRBNDDB1CREBBPBRD4ALDH1A1 | |
| SCHEMBL17276659 | 0.80 | MEN1 (0.37) | CRBNDDB1ALDH1A1MAPTKMT2A | |
| SCHEMBL9257109 | 0.78 | CREBBP (0.39) | CRBNDDB1CREBBPBRD4ALDH1A1 | |
| SCHEMBL9260097 | 0.78 | ALDH1A1 (0.40) | CRBNDDB1ALDH1A1MAPTHPGD | |
| SCHEMBL17276398 | 0.78 | ALDH1A1 (0.36) | CRBNDDB1CREBBPALDH1A1MAPT | |
| SCHEMBL9251370 | 0.78 | DDB1 (0.55) | CRBNDDB1ALDH1A1MAPTHPGD | |
| SCHEMBL9253505 | 0.78 | DDB1 (0.55) | CRBNDDB1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015179293-A1 | SMALL MOLECULE ACTIVATORS AND INHIBITORS OF LECITHIN: CHOLESTEROL ACYLTRANSFERASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-11-26 | — | — | WO | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| US-5591881-A | DEGRADING TRIALKYLSILYL PROTECTED-THREONINE WITH NINHYDRIN; PERFORMING HONOR-WORDSWORTH-EMONS REACTION | CHOONGWAE PHARMACEUTICAL CO., LTD. (KR) | 1997-01-07 | — | — | US | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |
| WO-1995002579-A1 | SUBSTITUTED AZETIDINONE AMIDE DERIVATIVES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | ZENECA LIMITED (GB) | 1995-01-26 | — | — | WO | disclosed |
| EP-0282241-B1 | BETA-LACTAM COMPOUNDS AND PRODUCTION PROCESS THEREOF | Tamura, Yasumitsu (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4918184-A | REACTING 1,3-THIAZOLIDINE-2-THIONE DERIVATIVE WITH TIN TRIFLUOROMETHANESULFONATE TO FORM ENOLATE, REACTING WITH SUBSTITUTED AZETIDINONE | LEDERLE (JAPAN), LTD. (JP) | 1990-04-17 | — | — | US | disclosed |
| EP-0213610-A1 | Azetidin-2-one derivatives and process for production thereof | LEDERLE (JAPAN) LTD. (JP) | 1987-03-11 | — | — | EP | disclosed |
| EP-0045198-A2 | 1,1-Disubstituted carba-2-penems and their production | Takeda Chemical Industries, Ltd. (JP) | 1982-02-03 | — | — | EP | disclosed |