Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 10/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961105 | 0.84 | GCGR (0.50) | GCGR | |
| SCHEMBL10587714 | 0.82 | MAPK14 (0.40) | GCGRMAPK14KDM4EALDH1A1PRKCZ | |
| SCHEMBL9271574 | 0.81 | PRKCZ (0.50) | HMGCRGCGRMAPK14KDM4EALDH1A1 | |
| SCHEMBL6953892 | 0.80 | GCGR (0.61) | GCGR | |
| SCHEMBL6951556 | 0.79 | KDM4E (0.40) | MAPK14KDM4EALDH1A1HPGDALOX15 | |
| SCHEMBL6961920 | 0.79 | GCGR (0.51) | GCGR | |
| SCHEMBL6962775 | 0.76 | GCGR (0.48) | GCGR | |
| SCHEMBL9410045 | 0.76 | GCGR (0.50) | GCGR | |
| SCHEMBL6958555 | 0.76 | GCGR (0.61) | HMGCRGCGR | |
| SCHEMBL6963303 | 0.76 | GCGR (0.50) | HMGCRGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325130-B1 | Substituted pyridines | BAYER AG (DE) | 2003-11-05 | — | — | EP | disclosed |
| EP-1123925-A1 | Process for preparation of substituted pyridines | BAYER AG (DE) | 2001-08-16 | — | — | EP | disclosed |
| EP-1123924-A1 | Substituted pyridines as HMG-COA reductase inhibitors | BAYER AG (DE) | 2001-08-16 | — | — | EP | disclosed |