Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 20/20 | 0.82 |
| ▸ | ADRA1B | P35368 | 19/20 | 0.82 |
| ▸ | ADRA1D | P25100 | 18/20 | 0.82 |
| ▸ | HRH1 | P35367 | 4/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954383 | 0.90 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7658901 | 0.90 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL14587407 | 0.86 | ADRA1A (0.89) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7212035 | 0.85 | ADRA1A (0.59) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL5663201 | 0.82 | ADRA1A (0.76) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7068048 | 0.82 | ADRA1A (0.76) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7068045 | 0.82 | ADRA1A (0.76) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7233750 | 0.82 | ADRA1A (0.56) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7226018 | 0.80 | ADRA1A (0.80) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7966480 | 0.75 | ADRA1A (0.72) | ADRA1AADRA1BADRA1DHRH1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |