Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 18/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 17/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 16/20 | 1.00 |
| ▸ | HRH1 | P35367 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.58 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954383 | 1.00 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL14587407 | 0.94 | ADRA1A (0.89) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL6961810 | 0.90 | ADRA1A (0.82) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7226018 | 0.89 | ADRA1A (0.80) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL5663201 | 0.87 | ADRA1A (0.76) | ADRA1AADRA1BADRA1DHRH1MCHR1 | |
| SCHEMBL7068045 | 0.87 | ADRA1A (0.76) | ADRA1AADRA1BADRA1DHRH1MCHR1 | |
| SCHEMBL7068048 | 0.87 | ADRA1A (0.76) | ADRA1AADRA1BADRA1DHRH1MCHR1 | |
| SCHEMBL7966480 | 0.84 | ADRA1A (0.72) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7952342 | 0.84 | ADRA1A (0.72) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7952365 | 0.84 | ADRA1A (0.72) | ADRA1AADRA1BADRA1DHRH1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372911-B1 | REACTING COMPOUND CONTAINING AT LEAST ONE CARBON-CARBON DOUBLE BOND WITH CARBAMATE IN AQUEOUS SOLVENT IN PRESENCE OF BASE, OSMIUM CATALYST, CO-OXIDANT, AND OPTIONALLY ASYMMETRIC LIGAND, TO FORM REACTION MIXTURE CONTAINING BETA-HYDROXY CARBAMATE | MERCK & CO., INC. | 2002-04-16 | — | — | US | disclosed |
| US-6329393-B1 | ADRENERGIC AGENTS TREATMENT OF BENIGN PROSTATIC HYPERPLASIA. | MERCK & CO., INC. | 2001-12-11 | — | — | US | disclosed |