Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18623686 | 0.87 | NPC1 (0.50) | NPC1RAB9AKLK7SMN1; SMN2ALDH1A1 | |
| SCHEMBL6965688 | 0.83 | EPHX2 (0.40) | NPC1RAB9AKLK7EPHX2SMN1; SMN2 | |
| SCHEMBL2828069 | 0.81 | KDM4E (0.44) | NPC1RAB9AKLK7EPHX2SMN1; SMN2 | |
| SCHEMBL15719546 | 0.75 | ALDH1A1 (0.43) | NPC1RAB9AEPHX2SMN1; SMN2ALDH1A1 | |
| SCHEMBL724170 | 0.75 | ALDH1A1 (0.43) | NPC1RAB9AEPHX2SMN1; SMN2ALDH1A1 | |
| SCHEMBL6966443 | 0.75 | ALDH1A1 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1EGFR | |
| SCHEMBL691738 | 0.74 | HTT (0.44) | NPC1RAB9AEPHX2SMN1; SMN2ALDH1A1 | |
| SCHEMBL23716391 | 0.73 | MAPT (0.40) | NPC1RAB9AEPHX2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2029748 | 0.72 | PPARA (0.41) | NPC1RAB9AEPHX2SMN1; SMN2ALDH1A1 | |
| SCHEMBL18231248 | 0.71 | NPC1 (0.44) | NPC1RAB9AEPHX2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |