Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 13/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961982 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL17808122 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL6963872 | 0.82 | MAPT (0.65) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL6963874 | 0.82 | MAPT (0.65) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL5754525 | 0.80 | HPGD (0.50) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL20583519 | 0.79 | CASP6 (0.60) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL20583518 | 0.79 | CASP6 (0.60) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL4554299 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL14938472 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL28657822 | 0.78 | KMT2A (0.49) | SMN1; SMN2HTTMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023063-B1 | INDENO[1,2-c], NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES | ABBOTT GMBH & CO KG (DE) | 2003-09-10 | — | — | EP | disclosed |