Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 12/20 | 0.66 |
| ▸ | RAB9A | P51151 | 10/20 | 0.66 |
| ▸ | NPC1 | O15118 | 8/20 | 0.66 |
| ▸ | GAA | P10253 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205815 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL23678214 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL14938579 | 0.84 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL23658108 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL4734168 | 0.81 | SMN1; SMN2 (0.80) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL20520189 | 0.81 | SMN1; SMN2 (0.80) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL4734171 | 0.81 | SMN1; SMN2 (0.80) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL11606920 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL6961982 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTMAPTRAB9ANPC1 | |
| SCHEMBL6961978 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-11-03 | — | — | US | disclosed |
| US-9421211-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-08-23 | — | — | US | disclosed |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | NSUN2, EIF2AK2, RNGTT | SMN1; SMN2 850/4885HTT 171/4885MAPT 1631/4885 |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | NSUN2, EIF2AK2, RNGTT | SMN1; SMN2 850/4885HTT 171/4885MAPT 1631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.