Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 8/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961978 | 0.80 | SMN1; SMN2 (0.67) | ALDH1A1MAPTPKMCASP6SMN1; SMN2 | |
| SCHEMBL6961982 | 0.80 | SMN1; SMN2 (0.67) | ALDH1A1MAPTPKMCASP6SMN1; SMN2 | |
| SCHEMBL20583518 | 0.74 | CASP6 (0.60) | ALDH1A1MAPTPKMCASP6SMN1; SMN2 | |
| SCHEMBL20583519 | 0.74 | CASP6 (0.60) | ALDH1A1MAPTPKMCASP6SMN1; SMN2 | |
| SCHEMBL29354952 | 0.73 | CTSL (0.67) | HPGDNPSR1ALDH1A1MAPTPLA2G1B | |
| SCHEMBL28865215 | 0.73 | CTSL (0.67) | HPGDNPSR1ALDH1A1MAPTPLA2G1B | |
| SCHEMBL12609454 | 0.70 | MAPT (0.71) | HPGDNPSR1ALDH1A1MAPTPLA2G1B | |
| SCHEMBL15595501 | 0.69 | SMN1; SMN2 (0.57) | HPGDALDH1A1MAPTPLA2G1BATG4B | |
| SCHEMBL13114093 | 0.68 | HPGD (0.68) | HPGDNPSR1ALDH1A1MAPTPLA2G1B | |
| SCHEMBL7971943 | 0.68 | HPGD (1.00) | HPGDNPSR1ALDH1A1MAPTPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325002-B1 | 1,2,5,10-TETRAHYDROPYRIDAZINO¬4,5-B|QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-05-24 | — | — | EP | disclosed |
| US-6833368-B2 | Tackykinin antagonist | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |
| US-20040058927-A1 | 1, 2, 5, 10-tetrahydropyridazino[4, 5-b]quinoline-1,10-diones and their use for the treatment of pain | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | US | disclosed |
| EP-1325002-A1 | 1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-B]QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002026738-A1 | 1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-b]QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2002-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058927-A1 | 1, 2, 5, 10-tetrahydropyridazino[4, 5-b]quinoline-1,10-diones and their use for the treatment of pain | OPRK1, OPRM1, OPRD1 | HPGD 580/4885NPSR1 583/4885ALDH1A1 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.