SCHEMBL696210

SCHEMBL696210

O=C(Cl)c1sc2ccccc2c1C(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.47
HDAC1 Q13547 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
LIMK1 P53667 2/20 0.44
IKBKB O14920 1/20 0.44
OGG1 O15527 1/20 0.43
LMNA P02545 1/20 0.41
MAPK1 P28482 1/20 0.41
GABRA1 P14867 1/20 0.40
GABRA5 P31644 1/20 0.40
CD274 Q9NZQ7 1/20 0.40
MAPT P10636 3/20 0.40
KDM4E B2RXH2 2/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
GLA P06280 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17938613 0.86 LIMK1 (0.46) MCL1HDAC1HDAC8HDAC6LIMK1
SCHEMBL13736548 0.85 MCL1 (0.57) MCL1HDAC1HDAC8HDAC6LIMK1
SCHEMBL28885146 0.83 LIMK1 (0.60) MCL1HDAC1HDAC8HDAC6LIMK1
SCHEMBL144003 0.80 MCL1 (0.42) MCL1GABRA1GABRA5MAPTKDM4E
SCHEMBL15697557 0.80 LMNA (0.63) HDAC1HDAC8HDAC6LIMK1LMNA
SCHEMBL903483 0.78 BCL2L1 (0.42) MCL1LMNAMAPTKDM4EALDH1A1
SCHEMBL27629193 0.75 MCL1 (0.53) MCL1HDAC1HDAC8HDAC6LIMK1
SCHEMBL64428 0.75 MCL1 (0.73) MCL1HDAC1HDAC8HDAC6OGG1
SCHEMBL2610245 0.74 RXFP1 (0.59) MCL1HDAC1HDAC8HDAC6LIMK1
SCHEMBL30980091 0.74 PTGS2 (0.56) MCL1HDAC1HDAC8HDAC6LIMK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4087841-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS Syngenta Crop Protection AG (CH) 2022-11-16 EP disclosed
EP-2421852-A1 HETEROAROMATIC AND AROMATIC PIPERAZINYL AZETIDINYL AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITOR Janssen Pharmaceutica N.V. (BE) 2012-02-29 EP disclosed
WO-2010124121-A1 HETEROAROMATIC AND AROMATIC PIPERAZINYL AZETIDINYL AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITOR JANSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed