Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2610282 | 0.87 | MCL1 (0.50) | BCL2L1MCL1NPC1RAB9AKIF11 | |
| SCHEMBL144003 | 0.84 | MCL1 (0.42) | MCL1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL17149271 | 0.83 | LMNA (0.44) | BCL2L1MCL1MAPTLMNAGAA | |
| SCHEMBL696210 | 0.78 | MCL1 (0.47) | MCL1NPC1RAB9AMAPTLMNA | |
| SCHEMBL2610280 | 0.75 | MCL1 (0.61) | BCL2L1MCL1NPC1RAB9AMAPT | |
| SCHEMBL15147237 | 0.73 | BCKDK (0.41) | MCL1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL148094 | 0.72 | MCL1 (0.53) | BCL2L1MCL1MAPTKDM4EMAOB | |
| SCHEMBL18791342 | 0.71 | BCL2L1 (0.47) | BCL2L1MCL1NPC1RAB9AMAPT | |
| SCHEMBL3685281 | 0.70 | MAPT (0.45) | MCL1NPC1RAB9AMAPTLMNA | |
| SCHEMBL160072 | 0.70 | CMA1 (0.44) | MCL1NPC1RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044613-A1 | OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | WO | disclosed |