Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | HTR1D | P28221 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MARK3 | P27448 | 1/20 | 0.53 |
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.53 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392593 | 0.76 | JAK2 (0.69) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL6954562 | 0.75 | DRD2 (0.56) | HTR2CHTR6DRD2HTR1B | |
| SCHEMBL6960967 | 0.75 | DRD2 (0.48) | HTR2CHTR6DRD2HTR1B | |
| SCHEMBL6631651 | 0.74 | KDM4E (0.70) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL9093496 | 0.73 | ALDH1A1 (0.56) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL9094194 | 0.72 | HTR6 (0.55) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL9094655 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL9094872 | 0.72 | JAK2 (0.55) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL2778860 | 0.71 | HTR6 (0.67) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL3836149 | 0.71 | HTR6 (0.67) | KDM4EALDH1A1HTR2CHSD17B10HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |