Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CTSL | P07711 | 2/20 | 0.59 |
| ▸ | CTSB | P07858 | 2/20 | 0.59 |
| ▸ | CTSS | P25774 | 2/20 | 0.59 |
| ▸ | MMP3 | P08254 | 11/20 | 0.54 |
| ▸ | MMP1 | P03956 | 4/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708271 | 1.00 | MEN1 (0.60) | MEN1KMT2ALMNACTSLCTSB | |
| SCHEMBL7360914 | 0.95 | MEN1 (0.55) | MEN1KMT2ALMNACTSLCTSB | |
| SCHEMBL7360919 | 0.95 | MEN1 (0.55) | MEN1KMT2ALMNACTSLCTSB | |
| SCHEMBL6968692 | 0.91 | MMP3 (0.56) | CTSLCTSSMMP3MMP1MMP2 | |
| SCHEMBL6968687 | 0.91 | MMP3 (0.56) | CTSLCTSSMMP3MMP1MMP2 | |
| SCHEMBL6958535 | 0.83 | MMP3 (0.57) | CTSLCTSSMMP3MMP1MMP2 | |
| SCHEMBL6961631 | 0.83 | CTSK (0.59) | CTSLCTSBCTSSMMP3MMP1 | |
| SCHEMBL6961636 | 0.83 | CTSK (0.59) | CTSLCTSBCTSSMMP3MMP1 | |
| SCHEMBL6958538 | 0.83 | MMP3 (0.57) | CTSLCTSSMMP3MMP1MMP2 | |
| SCHEMBL7361337 | 0.83 | MMP3 (0.64) | MMP3MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | claimed |
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | disclosed |