Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CTSB | P07858 | 3/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
| ▸ | MMP3 | P08254 | 8/20 | 0.50 |
| ▸ | MMP1 | P03956 | 4/20 | 0.50 |
| ▸ | CASP3 | P42574 | 4/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | CASP9 | P55211 | 2/20 | 0.47 |
| ▸ | CASP6 | P55212 | 2/20 | 0.47 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | CASP4 | P49662 | 1/20 | 0.47 |
| ▸ | CASP5 | P51878 | 1/20 | 0.47 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360914 | 1.00 | MEN1 (0.55) | MEN1KMT2ALMNACTSBCTSL | |
| SCHEMBL8708271 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACTSBCTSL | |
| SCHEMBL6962422 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACTSBCTSL | |
| SCHEMBL6968692 | 0.93 | MMP3 (0.56) | CTSLCTSSMMP3MMP1CASP3 | |
| SCHEMBL6968687 | 0.93 | MMP3 (0.56) | CTSLCTSSMMP3MMP1CASP3 | |
| SCHEMBL7361337 | 0.87 | MMP3 (0.64) | MMP3MMP1MMP2 | |
| SCHEMBL7361333 | 0.87 | MMP3 (0.64) | MMP3MMP1MMP2 | |
| SCHEMBL7365921 | 0.86 | CTSK (0.59) | CTSBCTSLCTSSMMP3MMP1 | |
| SCHEMBL7364811 | 0.86 | CTSK (0.59) | CTSBCTSLCTSSMMP3MMP1 | |
| SCHEMBL7357736 | 0.85 | MMP3 (0.65) | CTSBCTSLCTSSMMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998025949-A1 | SUBSTITUTED 5-AMINO-1,3,4-THIADIAZOLE-2-THIONES | PROSCRIPT, INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0845002-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1998-06-03 | — | — | EP | disclosed |
| US-5677282-A | ENZYME INHIBITOR; OSTEOARTHRITIS AND RHEUMATIC DISORDERS | PROSCRIPT, INC. (US) | 1997-10-14 | — | — | US | disclosed |
| WO-1996040745-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1996-12-19 | — | — | WO | disclosed |