Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.68 |
| ▸ | ACHE | P22303 | 2/20 | 0.68 |
| ▸ | BACE1 | P56817 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695065 | 0.85 | MEN1 (0.68) | BCHEACHEBACE1POLBMEN1 | |
| SCHEMBL6110591 | 0.84 | BCHE (0.51) | BCHEACHEBACE1KDM4EPOLB | |
| SCHEMBL695671 | 0.84 | MEN1 (0.52) | BCHEACHEBACE1KDM4EPOLB | |
| SCHEMBL736332 | 0.83 | MEN1 (0.54) | BCHEACHEBACE1KDM4EPOLB | |
| SCHEMBL7000552 | 0.79 | KDM4E (0.69) | BCHEKDM4EPOLBMEN1KMT2A | |
| SCHEMBL735991 | 0.78 | KDM1A (0.61) | BCHEACHEBACE1KDM4EPOLB | |
| SCHEMBL680393 | 0.78 | ALDH1A1 (0.58) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL29875218 | 0.78 | ALDH1A1 (0.58) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL27091860 | 0.77 | MEN1 (0.65) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL18901363 | 0.76 | ALDH1A1 (0.56) | BCHEKDM4EPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013084241-A1 | COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2013-06-13 | — | — | WO | disclosed |
| US-20120115907-A1 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2012-05-10 | — | — | US | disclosed |
| EP-2421828-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF RENIN | Cadila Healthcare Limited (IN) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122580-A2 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |
| CN-1780833-A | Tropane derivatives and their use as ace inhibitors | ACTELION PHARMACEUTICALS LTD (CH) | 2006-05-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115907-A1 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | REN, ACE, AGTR1 | BCHE 1870/4885ACHE 1313/4885BACE1 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.