Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.59 |
| ▸ | MST1R | Q04912 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167642 | 0.97 | MET (0.62) | METMST1RAXLKDREGFR | |
| Trifluoroacetic Acid SCHEMBL697610 | 0.93 | MET (0.59) | METMST1RAXLKDRKIT | |
| SCHEMBL168714 | 0.89 | MET (0.63) | METMST1RAXLKDRKIT | |
| Trifluoroacetic Acid SCHEMBL696273 | 0.87 | AXL (0.58) | METMST1RAXLKDREGFR | |
| Trifluoroacetic Acid SCHEMBL703131 | 0.84 | MET (0.61) | METMST1RKDRFLT3 | |
| Trifluoroacetic Acid SCHEMBL698719 | 0.82 | MET (0.70) | METKDREGFRPDGFRBKIT | |
| SCHEMBL168401 | 0.82 | AXL (0.61) | METMST1RAXLKDREGFR | |
| Trifluoroacetic Acid SCHEMBL705178 | 0.80 | AXL (0.64) | METMST1RAXLKDRKIT | |
| Trifluoroacetic Acid SCHEMBL695728 | 0.80 | MET (0.61) | METMST1RAXLKDRKIT | |
| SCHEMBL166037 | 0.80 | MET (0.64) | METAXLKDREGFRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |
| EP-2423208-A1 | Pharmaceutically active compounds as Axl inhibitors | Lead Discovery Center GmbH (DE) | 2012-02-29 | — | — | EP | disclosed |