Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.38 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086170 | 0.74 | KDM4E (0.45) | RAB9AGAAMEN1KMT2AALDH1A1 | |
| Fumaric Acid SCHEMBL6962864 | 0.70 | CYP19A1 (0.49) | MAPTMAPK1NPC1RAB9ALMNA | |
| Fumaric Acid SCHEMBL6962854 | 0.70 | CYP19A1 (0.49) | MAPTMAPK1NPC1RAB9ALMNA | |
| SCHEMBL3209460 | 0.66 | RAB9A (0.62) | MAPTMAPK1NPC1RAB9APLIN1 | |
| SCHEMBL3209446 | 0.66 | RAB9A (0.62) | MAPTMAPK1NPC1RAB9APLIN1 | |
| SCHEMBL6950504 | 0.66 | CYP2A6 (0.55) | MAPTMAPK1NPC1RAB9APLIN1 | |
| SCHEMBL6950514 | 0.66 | CYP2A6 (0.55) | MAPTMAPK1NPC1RAB9APLIN1 | |
| SCHEMBL6070874 | 0.65 | MAPT (0.58) | MAPTMAPK1NPC1RAB9APLIN1 | |
| SCHEMBL6070869 | 0.65 | MAPT (0.58) | MAPTMAPK1NPC1RAB9APLIN1 | |
| SCHEMBL9110304 | 0.65 | CYP3A4 (0.62) | MAPTMAPK1NPC1RAB9APLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974584-B1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6420375-B1 | ANTITUMOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-0974584-A1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-01-26 | — | — | EP | disclosed |