Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 14/20 | 0.50 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080575 | 0.80 | ADRA1A (0.48) | ADRA1ADRD4ADRA1BADRA1DDRD2 | |
| SCHEMBL7212047 | 0.76 | ADRA1A (0.60) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7080576 | 0.75 | ADRA1A (0.46) | ADRA1ADRD4ADRA1BADRA1DDRD2 | |
| SCHEMBL7966207 | 0.75 | ADRA1A (0.63) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7966205 | 0.75 | ADRA1A (0.63) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7959697 | 0.75 | ADRA1A (0.65) | ADRA1AADRA1BADRA1DDRD2HRH1 | |
| SCHEMBL7966238 | 0.75 | ADRA1A (0.63) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7218158 | 0.75 | ADRA1A (0.47) | ADRA1ADRD4ADRA1BADRA1DDRD2 | |
| Hydrochloric Acid SCHEMBL7965667 | 0.75 | ADRA1A (0.62) | ADRA1AADRA1BADRA1DHRH1 | |
| Hydrochloric Acid SCHEMBL7965663 | 0.75 | ADRA1A (0.62) | ADRA1AADRA1BADRA1DHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |