Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 7/20 | 0.46 |
| ▸ | DRD4 | P21917 | 11/20 | 0.42 |
| ▸ | DRD2 | P14416 | 9/20 | 0.42 |
| ▸ | DRD3 | P35462 | 6/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962974 | 0.75 | ADRA1A (0.50) | ADRA1ADRD4DRD2DRD3ADRA1D | |
| SCHEMBL7080575 | 0.74 | ADRA1A (0.48) | ADRA1ADRD4DRD2DRD3ADRA1D | |
| SCHEMBL6196064 | 0.68 | DRD4 (0.52) | ADRA1ADRD4DRD2DRD3ADRA1D | |
| SCHEMBL7212047 | 0.67 | ADRA1A (0.60) | ADRA1AADRA1DADRA1B | |
| Cadaverine Tartrate SCHEMBL7640622 | 0.67 | ADRA1A (0.53) | ADRA1ADRD4DRD2DRD3ADRA1D | |
| SCHEMBL7212038 | 0.67 | DRD4 (0.59) | ADRA1ADRD4DRD2DRD3ADRA1D | |
| SCHEMBL8142705 | 0.67 | ADRA1A (0.53) | ADRA1ADRD4DRD2DRD3ADRA1D | |
| Hydrochloric Acid SCHEMBL8181520 | 0.67 | DRD4 (0.51) | ADRA1ADRD4DRD2DRD3ADRA1D | |
| Hydrochloric Acid SCHEMBL7660487 | 0.67 | DRD4 (0.51) | ADRA1ADRD4DRD2DRD3ADRA1D | |
| SCHEMBL7218158 | 0.66 | ADRA1A (0.47) | ADRA1ADRD4DRD2DRD3ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |