Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953006 | 0.90 | KEAP1 (0.48) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7374971 | 0.80 | SMN1; SMN2 (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL6954426 | 0.76 | PPARG (0.49) | SMN1; SMN2PPARGPPARACYP2C19POLB | |
| SCHEMBL10484039 | 0.75 | ANPEP (0.49) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7078774 | 0.75 | GRIK1 (0.57) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL1856639 | 0.75 | GRIK1 (0.72) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL8534946 | 0.73 | NOS1 (0.59) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL28721831 | 0.73 | KEAP1 (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL11449291 | 0.73 | SMN1; SMN2 (0.49) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL6578386 | 0.73 | GRIK1 (0.59) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |