SCHEMBL6953006

SCHEMBL6953006

O=C(O)C(SCCc1ccccc1)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.48
CYP1A2 P05177 1/20 0.47
HDAC2 Q92769 2/20 0.45
HDAC8 Q9BY41 2/20 0.45
HDAC6 Q9UBN7 2/20 0.45
HDAC3 O15379 1/20 0.45
MAPK1 P28482 1/20 0.45
ADRA1A P35348 1/20 0.45
HDAC4 P56524 1/20 0.45
SLC6A3 Q01959 1/20 0.45
HDAC1 Q13547 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45
HDAC9 Q9UKV0 1/20 0.45
HDAC5 Q9UQL6 1/20 0.45
ALDH1A1 P00352 1/20 0.45
FFAR1 O14842 1/20 0.45
GRIK1 P39086 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6963211 0.90 HDAC3 (0.50) KEAP1HDAC2HDAC8HDAC6HDAC3
SCHEMBL28721831 0.82 KEAP1 (0.47) KEAP1CYP1A2HDAC2HDAC8HDAC6
SCHEMBL6954426 0.81 PPARG (0.49) CYP1A2SMN1; SMN2CES1ALPIPKM
SCHEMBL1863852 0.79 PPARG (0.45) KEAP1CYP1A2SMN1; SMN2CYSLTR2CYSLTR1
SCHEMBL7370964 0.78 SMN1; SMN2 (0.50) CYP1A2SMN1; SMN2ALDH1A1TDP1MAPT
SCHEMBL9613875 0.73 MAPT (0.50) HDAC2HDAC8HDAC6HDAC3MAPK1
Cadaverine Tartrate SCHEMBL3721240 0.71 FFAR1 (0.56) KEAP1CYP1A2HDAC2HDAC8HDAC6
SCHEMBL12793341 0.71 CYP1A2 (0.45) CYP1A2SLC6A3SMN1; SMN2ALDH1A1TDP1
SCHEMBL2291948 0.71 MMP8 (0.56) KEAP1CYP1A2HDAC2HDAC8HDAC6
SCHEMBL1856639 0.71 GRIK1 (0.72) CYP1A2HDAC2HDAC8HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
US-6005103-A TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS WARNER-LAMBERT COMPANY (US) 1999-12-21 US disclosed
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed