Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 9/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389166 | 0.90 | SYK (0.51) | CASP1SYKCTRB1ATMELANE | |
| SCHEMBL7681968 | 0.90 | SYK (0.51) | CASP1SYKCTRB1ATMELANE | |
| SCHEMBL14569563 | 0.87 | CTRB1 (0.59) | SYKCTRB1ATMELANECTSL | |
| SCHEMBL12564718 | 0.87 | SYK (0.60) | SYKCTRB1ATMELANECTSL | |
| SCHEMBL21372402 | 0.87 | SYK (0.53) | SYKCTRB1ATMELANECTSL | |
| SCHEMBL13219608 | 0.87 | SYK (0.60) | SYKCTRB1ATMELANECTSL | |
| SCHEMBL13036482 | 0.87 | CTRB1 (0.59) | SYKCTRB1ATMELANECTSL | |
| SCHEMBL12142665 | 0.87 | SYK (0.53) | SYKCTRB1ATMELANECTSL | |
| SCHEMBL12798896 | 0.87 | SYK (0.57) | CASP1SYKCTRB1ATMELANE | |
| SCHEMBL13036484 | 0.86 | CTSK (0.62) | SYKATMELANECTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-1021424-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997048688-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |