Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29818828 | 1.00 | LMNA (0.58) | LMNATSHRATMNPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29818605 | 0.97 | LMNA (0.56) | LMNATSHRATMNPSR1ALDH1A1 | |
| SCHEMBL14124159 | 0.88 | LMNA (0.56) | LMNATSHRATMNPSR1ALDH1A1 | |
| SCHEMBL4722654 | 0.83 | ATM (0.66) | LMNATSHRATMNPSR1ALDH1A1 | |
| SCHEMBL30719637 | 0.83 | ATM (0.66) | LMNATSHRATMNPSR1ALDH1A1 | |
| SCHEMBL23840179 | 0.80 | IDO1 (0.55) | ALDH1A1KDM4EGAAHPGDMAPK1 | |
| SCHEMBL30719643 | 0.78 | LMNA (0.59) | LMNATSHRATMNPSR1ALDH1A1 | |
| SCHEMBL1789688 | 0.78 | LMNA (0.59) | LMNATSHRATMNPSR1ALDH1A1 | |
| SCHEMBL1786578 | 0.78 | ATM (0.73) | LMNATSHRATMNPSR1ALDH1A1 | |
| SCHEMBL14124140 | 0.76 | LMNA (0.61) | LMNATSHRATMNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111592562-B | Catalyst system of IVB group metal ligand containing phthalazinone structure and application thereof | 万华化学集团股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-111592562-A | Catalyst system of IVB group metal ligand containing phthalazinone structure and application thereof | 万华化学集团股份有限公司 | 2020-08-28 | — | — | CN | disclosed |
| EP-0946520-B1 | ISOQUINOLINAMINE AND PHTHALAZINAMINE DERIVATIVES WHICH INTERACT WITH CRF RECEPTORS | NEUROGEN CORP (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6440969-B2 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-08-27 | — | — | US | disclosed |
| US-6353103-B1 | STRESS RELATED DISORDERS SUCH AS POST TRAUMATIC STRESS DISORDER (PTSD) AS WELL AS DEPRESSION, HEADACHE AND ANXIETY. | NEUROGEN CORPORATION | 2002-03-05 | — | — | US | disclosed |
| US-20010036945-A1 | Certain Isoquinolinamine and phthalazinamine derivatives; corticotropin-releasing factor receptor CRF1 specific ligands | NEUROGEN CORPORATION. | 2001-11-01 | — | — | US | disclosed |
| US-6235752-B1 | CORTICOTROPIN RELEASING FACTOR; PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2001-05-22 | — | — | US | disclosed |
| US-6114530-A | ISOQUIOLINAMINES AND PHTHALAZINAMINES USEFUL IN TREATING STRESS RELATED DISORDERES SUCH AS POST TRAUMATIC STRESS DISORDER AS WELL AS DEPRESSION, HEADACHE AND ANXIETY | NEUROGEN CORPORATION (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0946520-A1 | ISOQUINOLINAMINE AND PHTHALAZINAMINE DERIVATIVES WHICH INTERACT WITH CRF RECEPTORS | NEUROGEN CORPORATION (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027066-A1 | ISOQUINOLINAMINE AND PHTHALAZINAMINE DERIVATIVES WHICH INTERACT WITH CRF RECEPTORS | NEUROGEN CORPORATION (US) | 1998-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010036945-A1 | Certain Isoquinolinamine and phthalazinamine derivatives; corticotropin-releasing factor receptor CRF1 specific ligands | CRHR1, CRH, CRHR2 | LMNA 4375/4885TSHR 213/4885ATM 3249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.