Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960170 | 0.98 | NAAA (0.43) | NAAAKCNH2CES2CES1EPHX1 | |
| SCHEMBL273784 | 0.94 | PCSK9 (0.39) | NAAACES2CES1EPHX1EPHX2 | |
| SCHEMBL271913 | 0.85 | ESR1 (0.37) | NAAACES2CES1ALDH1A1HTT | |
| SCHEMBL6965430 | 0.83 | NAAA (0.41) | NAAAKCNH2CES2CES1EPHX1 | |
| SCHEMBL8862115 | 0.82 | DRD2 (0.36) | NAAACES2CES1EPHX1EPHX2 | |
| SCHEMBL6972295 | 0.82 | NAAA (0.43) | NAAAKCNH2CES2CES1EPHX1 | |
| SCHEMBL28743025 | 0.82 | NAAA (0.43) | NAAAKCNH2CES2CES1EPHX1 | |
| SCHEMBL11780094 | 0.82 | NAAA (0.43) | NAAAKCNH2CES2CES1EPHX1 | |
| SCHEMBL11782714 | 0.80 | NAAA (0.42) | NAAAKCNH2CES2CES1EPHX1 | |
| SCHEMBL11781706 | 0.80 | NAAA (0.42) | NAAAKCNH2CES2CES1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |