Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312404 | 0.87 | ACHE (0.47) | LMNAKDM4EKMT2ASMN1; SMN2GAA | |
| SCHEMBL11224576 | 0.85 | CASR (0.55) | LMNAKDM4EKMT2ASMN1; SMN2MAPT | |
| SCHEMBL6966188 | 0.85 | HSD17B10 (0.48) | LMNAKDM4EKMT2ASMN1; SMN2GAA | |
| SCHEMBL23647320 | 0.80 | CASR (0.46) | LMNAKDM4EKMT2AGAAMAPT | |
| SCHEMBL7130164 | 0.74 | SMN1; SMN2 (0.68) | LMNAKMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL31478747 | 0.73 | MAPT (0.58) | LMNAKMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL11306755 | 0.73 | SMN1; SMN2 (0.55) | KDM4ESMN1; SMN2MAPTALDH1A1NPC1 | |
| SCHEMBL6955316 | 0.72 | RAB9A (0.52) | LMNAKDM4EKMT2ASMN1; SMN2GAA | |
| SCHEMBL5451782 | 0.72 | GAA (0.90) | LMNAKDM4EKMT2ASMN1; SMN2GAA | |
| SCHEMBL11319195 | 0.72 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2MAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| US-5714503-A | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 1998-02-03 | — | — | US | disclosed |
| US-5658907-A | THIOUREA VIRICIDES | MEDIVIR A/B (SE) | 1997-08-19 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993003022-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1993-02-18 | — | — | WO | disclosed |