Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.42 |
| ▸ | MMP3 | P08254 | 13/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965353 | 0.87 | MMP2 (0.46) | MMP2MMP3L3MBTL1MMP14ADAMTS5 | |
| SCHEMBL6433272 | 0.80 | MMP2 (0.44) | MMP2MMP3L3MBTL1MMP14ADAM10 | |
| SCHEMBL7452465 | 0.78 | ABL1 (0.33) | LMNA | |
| SCHEMBL6583989 | 0.75 | MMP2 (0.60) | MMP2MMP3L3MBTL1MMP14ADAMTS5 | |
| SCHEMBL6963483 | 0.72 | — | — | |
| SCHEMBL6586078 | 0.72 | MMP2 (0.64) | MMP2MMP3L3MBTL1MMP14ADAMTS5 | |
| SCHEMBL6437476 | 0.72 | MMP2 (0.49) | MMP2MMP3L3MBTL1LMNATHRB | |
| SCHEMBL6585837 | 0.71 | MMP2 (0.50) | MMP2MMP3L3MBTL1LMNATHRB | |
| SCHEMBL6584500 | 0.71 | MMP2 (0.53) | MMP2MMP3L3MBTL1MMP14ADAMTS5 | |
| SCHEMBL6440525 | 0.70 | MMP2 (0.59) | MMP2MMP3L3MBTL1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181017-B1 | METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-04-16 | — | — | EP | claimed |