Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.52 |
| ▸ | HRH1 | P35367 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.52 |
| ▸ | HTR2B | P41595 | 3/20 | 0.52 |
| ▸ | MTOR | P42345 | 3/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965971 | 0.93 | SLC6A4 (0.42) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL6961973 | 0.86 | HTR2A (0.68) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL8985947 | 0.83 | SLC6A4 (0.78) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL8195707 | 0.83 | HTR2A (0.70) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL6967959 | 0.82 | SLC6A4 (0.56) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL8196610 | 0.82 | SMPD1 (0.55) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL7168069 | 0.82 | MTNR1A (0.46) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL7168298 | 0.81 | HTR2A (0.66) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL8201084 | 0.80 | HTR2A (0.59) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL14732502 | 0.80 | SLC6A4 (0.57) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934312-B1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK AS (DK) | 2003-03-19 | — | — | EP | disclosed |
| US-6133268-A | 1,4-disubstituted piperazines | NOVO NORDISK A/S (DK) | 2000-10-17 | — | — | US | disclosed |
| US-6040302-A | ANTIINFLAMMATORY AGENTS TREATING RHEUMATOID ARTHRITIS, MIGRAINE OR ITCHING, INSULIN RESISTANCE IN NON-INSULIN-DEPENDENT DIABETES MELLITUS AND AGEING-ASSOCIATED OBESITY | NOVO NORDISK A/S (DK) | 2000-03-21 | — | — | US | disclosed |
| US-6004961-A | ANTIINFLAMMATORY AGENTS, ANALGESICS; NON-INSULIN-DEPENDENT DIABETES; AGE-RELATED OBESITY; DIBENZO(D,G)(1,3,6)DIOXAZOCINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1999-12-21 | — | — | US | disclosed |
| EP-0934312-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015548-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |