SCHEMBL8201084

SCHEMBL8201084

OCCCN1c2ccccc2CCCc2ccccc21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.59
CHRM2 P08172 8/20 0.54
CHRM1 P11229 8/20 0.54
CHRM3 P20309 8/20 0.54
CHRM4 P08173 7/20 0.54
CHRM5 P08912 7/20 0.54
SLC6A4 P31645 6/20 0.54
DRD2 P14416 5/20 0.54
DRD3 P35462 5/20 0.54
DRD4 P21917 4/20 0.54
SLC6A2 P23975 3/20 0.54
SLC22A2 O15244 2/20 0.54
SLC22A1 O15245 2/20 0.54
SLC22A3 O75751 2/20 0.54
CYP2D6 P10635 2/20 0.54
ADRA2B P18089 2/20 0.54
ADRA2C P18825 2/20 0.54
HTR2C P28335 2/20 0.54
ADRA1A P35348 2/20 0.54
HRH1 P35367 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6961973 0.93 HTR2A (0.68) HTR2ACHRM2CHRM1CHRM3CHRM4
SCHEMBL7168298 0.87 HTR2A (0.66) HTR2ACHRM2CHRM1CHRM3CHRM4
SCHEMBL7527914 0.82 CHRM1 (0.59) HTR2ACHRM2CHRM1CHRM3CHRM4
SCHEMBL5661091 0.81 CHRM2 (0.67) CHRM2CHRM1CHRM3CHRM4CHRM5
SCHEMBL6637686 0.81 HTR2A (0.61) HTR2ACHRM2CHRM1CHRM3CHRM4
SCHEMBL13051501 0.81 HTR2A (0.78) HTR2ACHRM2CHRM1CHRM3CHRM4
SCHEMBL5710968 0.80 ALDH1A1 (0.53) HTR2ACHRM2CHRM1CHRM3CHRM4
SCHEMBL909935 0.80 ALDH1A1 (0.53) HTR2ACHRM2CHRM1CHRM3CHRM4
SCHEMBL30634566 0.80 ALDH1A1 (0.53) HTR2ACHRM2CHRM1CHRM3CHRM4
SCHEMBL9083641 0.80 SLC6A1 (0.51) HTR2ASLC6A4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0738262-B1 NOVEL HETEROCYCLIC COMPOUNDS NOVO NORDISK AS (DK) 2000-04-19 EP disclosed
US-6043239-A N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS THEREOF IN WHICH A SUBSTITUTED ALKYL CHAIN FORMS PART OF THE N-SUBSTITUENT; TREATMENT OF PAINFUL, HYPERALGESIC AND/OR INFLAMMATORY CONDITIONS NOVO NORDISK A/S (DK) 2000-03-28 US disclosed
EP-0869777-A1 NOVEL METHOD NOVO NORDISK A/S (DK) 1998-10-14 EP disclosed
US-5668129-A ANTIINFLAMMATORY AGENTS, ANALGESICS OR ANTIDIABETIC AGENTS NOVO NORDISK A/S (DK) 1997-09-16 US disclosed
WO-1997022338-A1 NOVEL METHOD NOVO NORDISK A/S (DK) 1997-06-26 WO disclosed
US-5595989-A ANTIINFLAMMATORY AGENTS AND ANTIDIABETIC AGENTS NOVO NORDISK A/S (DK) 1997-01-21 US disclosed
EP-0738262-A1 NOVEL HETEROCYCLIC COMPOUNDS NOVO NORDISK A/S (DK) 1996-10-23 EP disclosed
WO-1995018793-A1 NOVEL HETEROCYCLIC COMPOUNDS NOVO NORDISK A/S (DK) 1995-07-13 WO disclosed